The thirteenth edition of the phenomenally successful Principles of 
Anatomy and Physiology  continues to set the standard for the discipline. The authors  maintained a superb balance between structure and function and continue  to emphasize the correlations between normal physiology and  pathophysiology, normal anatomy and pathology, and homeostasis and  homeostatic imbalances. The acclaimed illustration program continues to  be refined and is unsurpassed in the market. The thirteenth edition is  fully integrated with a host of innovative electronic media, including  WileyPlus 5.0 (access purchased separately.) No other text and package  offers a teaching and 
learning environment as rich and complete.
  Five Interesting Functions of the Human Body  - Most forms of color blindness, an inherited  inability to distinguish between certain colors, result from the absence  or deficiency of one of the types of cones. The most common type is  red-green color blindness, in which red cones or green cones are  missing. As a result, the person cannot distinguish between red and  green. Prolonged vitamin A deficiency and the resulting below-normal  amount of rhodopsin may cause night blindness or nyctalopia, an  inability to see well at low light levels.
 
- Women often have a keener sense of smell than men do, especially at  the time of ovulation. Smoking seriously impairs the sense of smell in  the short term and may cause long-term damage to olfactory receptors.  With aging the sense of smell deteriorates. Hyposmia, a  reduced ability to smell, affects half of those over age 65 and 75% of  those over age 80. Hyposmia also can be caused by neurological changes,  such as a head injury, Alzheimer disease, or Parkinson disease; certain  drugs, such as antihistamines, analgesics, or steroids; and the damaging  effects of smoking.
 
- Damage to the cerebellum can result in a loss of ability to  coordinate muscular movements, a condition called ataxia. Blindfolded  people with ataxia cannot touch the tip of their nose with their finger  because they cannot coordinate movement with their sense of where a body  part is located. Another sign of ataxia is a changed  speech pattern due to uncoordinated speech muscles. Cerebellar damage  may also result in staggering or abnormal walking movements. People who  consume too much alcohol show signs of ataxia because alcohol inhibits  activity of the cerebellum. Such individuals have difficulty in passing  sobriety tests. Ataxia can also occur as a result of degenerative  diseases (multiple sclerosis and Parkinson disease), trauma, brain  tumors, and genetic factors, and as a side effect of medication  prescribed for bipolar disorder.
 
- After death, the cellular membranes become leaky. Calcium ions leak  out of the sarcoplasmic reticulum into the sarcoplasm and allow myosin  heads to bind to actin. ATP synthesis ceases shortly after breathing  stops, however, so the cross-bridges cannot detach from actin. The  resulting condition, in which muscles are in a state of rigidity (cannot  contract or stretch), is called rigor mortis (rigidity  of death). Rigor mortis begins 3-4 hours after death and lasts about 24  hours; then it disappears as proteolytics enzymes from lysosomes digest  the cross-bridges.
 
- A dislocated mandible can occur in several ways. Anterior displacements  are the most common and occur when the condylar processes of the  mandible pass anterior to the articular tubercles. Common causes are  extreme mouth opening, as in yawning or taking a large bite, dental  procedures, or general anesthesia. Posterior displacement can be caused  by a direct blow to the chin. Superior displacements  can be caused by a direct blow to the chin. Superior displacements are  typically caused by a direct blow to a partially opened mouth. Lateral dislocations are usually associated with mandibular fractures
 
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